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In vitro inhibition of CLIPB9 by SRPN2 and mutants
| Protein | SI ± S.D. | ka ± S.D. | ka × SI ± S.D. |
|---|---|---|---|
| m−1 s−1 | m−1 s−1 | ||
| SRPN2-WT | 1.7 ± 0.1 | (1.5 ± 0.2) × 103 | (2.6 ± 0.2) × 103 |
| SRPN2-S358E | 2.5 ± 0.7 | (2.8 ± 0.3) × 103 | (7.1 ± 0.3) × 103 |
| SRPN2-S358W | 50 ± 12 | (6.1 ± 0.2) × 101 | (3.1 ± 0.1) × 103 |
| SRPN2-K198C/E359C | 20 ± 5 | (2.3 ± 0.4) × 102 | (4.6 ± 0.4) × 103 |
