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Schematic representation of the regulation of Skp2 by EBP50. Phosphorylation of Thr-156 in the PDZ2 domain of EBP50 by Akt allosterically promotes the interaction of Skp2 with PDZ1. Because EBP50 strongly interacts with cytoskeletal proteins this interaction induces cytoplasmic localization of Skp2 and increases Skp2 stability, ultimately leading to cell cycle progression.
