Skip to main content
. 2014 Dec 17;290(5):2784–2797. doi: 10.1074/jbc.M114.593384

FIGURE 2.

FIGURE 2.

The effect of the ARMS2 C/A variant on the HTRA1 transcription regulator. A, schematic diagram of the C/A variant plus HTRA1 regulatory element in the constructs used for luciferase assays (blue region, 600-bp AMRS2 transcription regulatory region (contains C/A variant); orange region, region that contains the HTRA1 regulatory element; yellow region, the luciferase reporter gene). B, C/A variant plus non-insertion/deletion type HTRA1 regulatory element activity in 661W cells. C, C/A variant plus insertion/deletion type HTRA1 regulatory element activity in 661W cells. Error bars, S.D. EV, empty vector; Normal, normal type C/A variant; Risk, risk type C/A variant; NI, non-insertion/deletion type HTRA1 regulatory element; I, insertion/deletion type HTRA1 regulatory element.