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. 2014 Dec 17;290(5):2784–2797. doi: 10.1074/jbc.M114.593384

FIGURE 5.

FIGURE 5.

HTRA1 transcription in human iPSCs derived from wet AMD patients. A, genotyping of non-insertion/deletion versus insertion/deletion versions of the human HTRA1 gene transcription regulatory region. B, detection of human iPSC marker genes by RT-PCR. Detection of GAPDH was used as an internal control. C, relative transcriptional level of HTRA1 determined by quantitative RT-PCR for iPSCs derived from individuals with non-insertion/deletion (control) versus insertion/deletion (wet AMD) transcription regulators. Sample 1, 30-year-old non-AMD male; sample 2, 72-year-old wet AMD female; sample 3, 38-year-old non-AMD male; sample 4, 71-year-old non-AMD female; sample 5, 71-year-old wet AMD female. Error bars, S.D.