. 2014 Jun 5;13(1):86–99. doi: 10.2450/2014.0260-13

Table IV.

Variables associated with response to first dose of rFVIIa and 28-day mortality in univariate and multivariate analyses.

	Univariate						Multivariate

Variables	Reported response			28-day mortality			Reported response			28-day mortality

	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value
*Bleeding context*
Cardiac surgery (ref)	1.00	-	-	1.00	-	-	1.00	-	-	1.00	-	-
Trauma	0.31	0.24, 0.40	<0.001	3.87	3.06, 4.89	<0.001	0.61	0.36, 1.03	0.062	1.48	0.87, 2.52	0.148
Obstetric	0.51	0.36, 0.73	<0.001	0.38	0.21, 0.67	0.001	0.75	0.40, 1.42	0.381	0.09	0.03, 0.29	<0.001
Intracranial haemorrhage	0.56	0.30, 1.04	0.069	4.36	2.69, 7.05	<0.001	0.23	0.067, 0.79	0.020	16.4	5.98, 45.1	<0.001
Medical/other	0.44	0.31, 0.62	<0.001	3.35	2.41, 4.67	<0.001	0.35	0.19, 0.62	0.001	3.52	1.89, 6.55	<0.001
Other surgery	0.49	0.39, 0.62	<0.001	2.58	2.06, 3.22	<0.001	0.72	0.45, 1.13	0.148	1.63	1.03, 2.58	0.037
Haematology/oncology	0.33	0.22, 0.49	<0.001	6.07	4.17, 8.82	<0.001	0.32	0.13, 0.78	0.014	15.9	6.22, 40.8	<0.001
Liver	0.33	0.23, 0.46	<0.001	4.18	3.02, 5.80	<0.001	0.35	0.18, 0.68	0.002	2.81	1.46, 5.39	0.002
*pH at time of dose (0.1 increase)*	1.64	1.53, 1.76	<0.001	0.58	0.54, 0.62	<0.001	1.46	1.29, 1.64	<0.001	0.59	0.53, 0.67	<0.001
*APTT prior to dose (30 sec increase)*	0.74	0.70, 0.79	<0.001	1.41	1.33, 1.48	<0.001	0.91	0.82, 1.01	0.068	1.19	1.08, 1.33	0.001
*Platelet level prior to dose (100×10⁹ increase)*	1.28	1.14, 1.43	<0.001	0.59	0.52, 0.67	<0.001	1.04	0.82, 1.31	0.765	0.55	0.43, 0.72	<0.001