. 2015 Jan 5;3(1):e00072. doi: 10.1002/prp2.72

Table 2.

Descriptive statistics of pharmacokinetic parameters for Sandoz MPH OCR and Concerta® in the fasting studies.

Parameter (Units) All mean ± SD	54-mg fasting (n = 24)		36-mg fasting (n = 22)		18-mg fasting (n = 24)
Parameter (Units) All mean ± SD	Sandoz MPH OCR	Concerta®	Sandoz MPH OCR	Concerta®	Sandoz MPH OCR	Concerta®
AUC_0–t (ng.h/mL)	116.70 ± 26.52	121.43 ± 27.00	89.37 ± 34.31	94.92 ± 32.85	39.89 ± 10.23	41.54 ± 9.90
AUC_0–inf (ng.h/mL)	121.98 ± 28.07	125.36 ± 28.12	95.72 ± 38.98	99.91 ± 36.19	41.52 ± 10.64	43.07 ± 10.58
C_max (ng/mL)	10.89 ± 2.09	12.11 ± 2.95	7.94 ± 2.79	8.39 ± 2.61	3.62 ± 0.81	3.76 ± 0.77
T_max (h)	5.81 ± 1.01	6.96 ± 1.56	5.70 ± 1.04	7.32 ± 1.49	5.65 ± 0.76	6.42 ± 1.49
K_el (h⁻¹)	0.1612 ± 0.0192	0.1811 ± 0.0199	0.1473 ± 0.0247	0.1634 ± 0.0211	0.1647 ± 0.0169	0.1781 ± 0.0200
T_{½ el} (h)	4.36 ± 0.55	3.88 ± 0.46	4.85 ± 0.93	4.32 ± 0.64	4.25 ± 0.43	3.94 ± 0.46
AUC_0–2 h (ng.h/mL)	6.59 ± 2.23	6.49 ± 2.18	4.93 ± 1.94	4.84 ± 1.51	2.26 ± 0.85	2.24 ± 0.83
AUC_2–24 h (ng.h/mL)	110.12 ± 24.85	114.93 ± 25.43	84.44 ± 32.96	90.08 ± 31.80	37.64 ± 9.64	39.29 ± 9.36
C_{max (0–2h)} (ng/mL)	5.43 ± 1.70	5.54 ± 1.86	4.00 ± 1.67	4.11 ± 1.24	1.88 ± 0.56	1.85 ± 0.57
C_{max (2–24h)} (ng/mL)	10.89 ± 2.09	12.11 ± 2.95	7.94 ± 2.79	8.39 ± 2.61	3.62 ± 0.81	3.76 ± 0.77