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. 2014 Nov 7;3(1):e00083. doi: 10.1002/prp2.83

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© 2014 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Schema for the cellular density-dependent regulation of HIF-1α, EP4 receptor, and PGE₂-induced COX-2 expression in HCA-7 cells. The expression of HIF-1α increased in a cellular density-dependent manner, whereas that of the EP4 receptors and PGE₂-induced COX-2 decreased.