Table 3.

Summary of 28-day lorcaserin treatment on clinical chemistry and major organ weights

	Clinical chemistry								Percent organ weights
	ALB	GLOB	AST	ALT	ALP	TBIL	BUN	CRE	Brain	Kidneys	Heart	Whole liver
Vehicle	40 ± 2	40 ± 2	117 ± 20	59 ± 13	176 ± 15	3.2 ± 0.8	5.9 ± 0.5	50.6 ± 5.7	0.30 ± 0.01	0.46 ± 0.02	0.26 ± 0.01	2.64 ± 0.09
Lorcaserin 1 mg/kg	40 ± 2	37 ± 2	106 ± 10	30 ± 3	175 ± 13	3.4 ± 0.6	5.4 ± 0.5	42.0 ± 2.4	0.29 ± 0.01	0.49 ± 0.01	0.25 ± 0.01	2.79 ± 0.12
Lorcaserin 2 mg/kg	33 ± 4	39 ± 3	90 ± 16	31 ± 7	160 ± 24	2.6 ± 0.6	5.1 ± 0.4	39.6 ± 8.7	0.30 ± 0.02	0.54 ± 0.03	0.27 ± 0.01	2.61 ± 0.09

These values all fall within normal range for SD rats (Petterino and Argentino-Storino 2006). ALB, albumin (g/L); GLOB, globulin (g/L); AST, aspartyl transaminase (U/L); ALT, alanine transaminase (U/L); ALP, alkaline phosphatase (U/L); TBIL, total bilirubin (μmol/L); BUN, blood urea nitrogen (mmol/L); CRE, creatinine (μmol/L).