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. 2015 Jan 5;3(1):e00108. doi: 10.1002/prp2.108

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© 2015 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Mouse locomotor activity test. Dose–response curve to PWT1-NPS (0.1–100 pmol, i.c.v., 15 min before starting the test). Time course of the distance travelled is shown in panel A. According to one-way ANOVA followed by the Dunnett’s post hoc test, PWT1-NPS elicited a statistically significant effect on the cumulative distance travelled (F_(4,32) = 7.95 0–60 min, B), total time immobile (F_(4,32) = 13.49 0–60 min; F_(4,32) = 2.70 60–120 min, C), and number of rearings (F_(4,32) = 12.20 0–60 min, D). Data are mean ± SEM of 7–8 mice per group, *P < 0.05 vs. saline.