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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Neuroscientist. 2014 Feb 7;20(5):534–545. doi: 10.1177/1073858413519865

Figure 4.

Figure 4

Role of estrogen receptor-alpha (ERα) and ERβ in transcription and cognition: studies using ERKO mice. (A) For ERβKO mice, the absence of ERβ results in a leftward shift in the descending arm of the dose–response curve. Ovariectomized ERβKO mice exhibit increased transcription of E2-sensitive genes and better cognition. Acute E2 treatment decreases transcription and fails to improve memory and chronic treatment impairs memory. (B) For ERαKO mice, the ascending arm of the dose response function for memory and 17β-estradiol (E2)- mediated transcription is shifted to the right. In this case, memory impairment is observed in low estrogen condition such as following ovariectomy and E2 treatment improves cognition and increases E2-sensitive transcription.