Skip to main content
. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Sci Transl Med. 2012 Oct 10;4(155):155ra138. doi: 10.1126/scitranslmed.3004414

Fig. 7.

Fig. 7

Detection of new HPV-specific functional CTL responses (quantitative killing assay). Delivery of active granzyme B from effectors to targets pulsed with HPV16 and HPV18 E6/E7 at varying E:T ratios: 10:1, 50:1, and 100:1. Whereas effector PBMCs isolated before immunization mediated little to no CTL activity in the form of granzyme B delivery (blue lines), postimmunization PBMCs were able to function as CTLs and deliver granzyme B to targets in an antigen-specific manner (red lines), suggesting an increased frequency of functional CTLs after immunization.