Table 1.
Sodium-glucose cotransporter 2 selectivity of sodium-glucose cotransporter 2 inhibitors
| Company | IC50 for human SGLT1/SGLT2 (nmol/L) | SGLT2 selectivity (fold) | |
| Phlorizin | 210/34.6 | 6 | |
| Ipragliflozin | Astellas | 1876/7.38 | 254 |
| canagliflozin | Johnson and Johnson Mitsubishi Tanabe | 684/4.4 | 155 |
| Dapagliflozin | Bristol-Myers Squibb AstraZeneca | 1391/1.12 | 1242 |
| Empagliflozin | Boehringer Ingelheim | 8300/3.1 | 2680 |
| Tofogliflozin | Chugai | 8444/2.9 | 2912 |
| luseogliflozin | Taisho | 3990/2.26 | 1770 |
SGLT2 selectivity was calculated by using the following formula: IC50 value for SGLT1/IC50 value for SGLT2. IC50: Half maximal (50%) inhibitory concentration; SGLT: Sodium–glucose cotransporter.