Table 2.
List of SNPs found in the genes of adiponectin pathway in metabolic disorders such as type 2 diabetes, obesity, dyslipidemia and cardiovascular disorders (coursey to http://www.genecards.org/ for providing the information regarding SNP loacation)
| Ref. | Gene | SL No. | Location | Variation | SNP ID |
| Blech et al[96] | PPARγ | 1 | Intron 1 | Pro12Ala | rs1801282 |
| Blech et al[96]; Ramya et al[81] | ADIPOQ | 1 2 3 4 5 6 7 8 9 | 5’ flanking region Intron 1 Intron 1 Intron 1 Exon 1 coding synonymous Intron 1 Intron 1 5’ flanking region Exon 3 splicing enhancers | −11365 C/G -4522 C/T -3971 A/G +276 G/T +45 T/G +349 A/G +712 G/A -11391 G/A Y111H T/C | rs266729 rs822393 rs822396 rs1501299 rs2241766 rs2241767 rs3774261 rs17300539 rs17366743 |
| Wang et al[97] | ADIPOR1 | 1 2 3 4 | Intron 1 Intron 1 Intron 1 5’ transcription factor binding site | +5646 A/G +5843 A/G -101 T/G -8503C/T | rs1342386 rs1342387 rs2275737 rs6666089 |
| Vaxillaire et al[98] | ADIPOR2 | 1 2 3 4 5 6 | Exon 3 splicing enhancers Intron 1 5’ flanking region Intron 1 Intron 1 Intron 1 | +33371 C/T +26314 A/G -64241 T/G +8645 G/C +14645 A/T -35361 G/A | rs12342 rs767870 rs1029629 rs1468491 rs4766415 rs10773982 |
| Thameem et al[99] | eNOS/NOS3 | 1 2 | Exon 3 splicing enhancers Intron 1 | Glu298Asp -786 T/C | rs1799983 rs2070744 |
| Zhang et al[100] | NF-kB | 1 | 5’ flanking region | -94 insertion/deletion | rs28362491 |
| Rees et al[101] | PEPCK | 1 | 5’ flanking region | -232C/G | rs2071023 |
| Jang et al[82] and Ferreira et al[83] | Apolipoprotein A5 gene (APOA5) | 1 | 5’ flanking region | -1131T/C | rs662799 |
| Ol et al[102] | COX-2 | 1 | 5’ flanking region | -765G/C | rs20417 |
| Ho et al[103] | IL4 | 1 | 5’ flanking region | -590 C/T | rs2243250 |
IL-6: Interleukin 6; AdipoR: Adiponectin receptors; eNOS: Endothelial nitric oxide synthase; PPARγ: Peroxisome proliferator-activated receptor gamma; COX2: Cyclooxygenase 2; NF-kβ: Nuclear factor kappa-light-chain-enhancer of activated B cells.