Fig. 2.

Immunohistochemical analysis of angiotensin AT_1a receptor and nuclear factor (NF)-κB protein expression in coronary vessels of hearts from Npr1^+/+ and Npr1^−/− mice. (a,e) Increased AT_1a receptor protein expression, (b,f) NF-κB protein expression, (c,g) perivascular fibrosis and (d,h) the number of inflammatory mast/monocyte infiltrating cells in coronary vessels of hearts from Npr1^−/− (a–d) and Npr1^+/+ (e–h) mice. (i) Mast/monocyte positive cells infiltration/section. Values are expressed as the mean ± SEM (n = 8). UT, untreated; HYZ, hydralazine; CAP, captopril. Reproduced with permission from Vellaichamy et al.¹⁶