Table 1. Family-based association results.
| Marker | Allele frequencies (%) | Genetic modela | S/E(S)b major allele | P-valuec major allele | S/E(S) minor allele | P-value minor allele |
|---|---|---|---|---|---|---|
| rs1043805 | A (85) | Additive | 331/336 | P=0.564 | 157/152 | P=0.564 |
| T (15) | Dominant | 40/43 | P=0.365 | 137/135 | P=0.791 | |
| rs3800373 | A (72) | Additive | 396/415.5 | P=0.060 | 264/244.5 | P=0.060 |
| C (28) | Dominant | 77/90.25 | P=0.010 | 182/175.75 | P=0.452 | |
| rs7757037 | G (52) | Additive | 447/414 | P=0.005 | 371/404 | P=0.005 |
| A (48) | Dominant | 175/167.25 | P=0.310 | 147/172.25 | P=0.001 | |
| rs3798346 | A (78) | Additive | 413/427.5 | P=0.137 | 225/210.5 | P=0.137 |
| G (22) | Dominant | 51/56.5 | P=0.177 | 174/165 | P= 0.285 | |
| rs9296158 | G (70) | Additive | 430/449 | P=0.083 | 294/275 | P=0.083 |
| A (30) | Dominant | 94/107 | P=0.020 | 200/194 | P=0.487 | |
| rs1360780 | C (70) | Additive | 402/417.5 | P=0.141 | 274/258.5 | P=0.141 |
| T (30) | Dominant | 87/97.25 | P=0.057 | 182/176.75 | P=0.526 | |
| rs4713902 | T (70) | Additive | 465/424 | P=0.0001 | 225/266 | P=0.0001 |
| C (30) | Dominant | 109/96.25 | P=0.019 | 147/175.25 | P=0.0007 | |
| rs6912833 | T (73) | Additive | 360/369.5 | P=0.335 | 234/224.5 | P=0.335 |
| A (27) | Dominant | 78/84 | P=0.228 | 160/156.5 | P= 0.654 | |
| rs9380525 | C (68) | Additive | 419/436.5 | P=0.110 | 305/287.5 | P=0.110 |
| G (32) | Dominant | 100/111.75 | P=0.044 | 192/186.25 | P=0.496 |
a
P-values for the recessive model are the inverse for those of the dominant model. For example, the recessive P-value for marker rs7757037 would be P = 0.001 for the major allele and P=0.310 for the minor allele.
b
S, test statistic for observed number of transmitted alleles as calculated by FBAT; E(S), expected value of S under the null hypothesis as calculated by FBAT.
c
P-values, asymptotic P-values as calculated by FBAT.