Table 2. Genotypic association results.
| Marker | Allele frequencies (%) | Genotypic association resultsa odds ratios (95% CI) | |||
|---|---|---|---|---|---|
|
|
|||||
| Homozygous major allele (reference) | Heterozygous | Homozygous minor allele | P-valueb | ||
| rs1043805 | A (85) | 1.0 | 0.78 (0.49, 1.23) | 0.76 (0.47, 1.24) | 0.53 |
| T (15) | |||||
| rs3800373 | A (72) | 1.0 | 1.05 (0.82, 1.34) | 1.66 (1.11, 2.46) | 0.03 |
| C (28) | |||||
| rs7757037 | G (52) | 1.0 | 0.68 (0.53, 0.87) | 0.63 (0.45, 0.89) | 0.007 |
| A (48) | |||||
| rs3798346 | A (78) | 1.0 | 0.75 (0.44, 1.29) | 0.67 (0.38, 1.19) | 0.35 |
| G (22) | |||||
| rs9296158 | G (70) | 1.0 | 1.04 (0.82, 1.32) | 1.53 (1.05, 2.22) | 0.05 |
| A (30) | |||||
| rs1360780 | C (70) | 1.0 | 1.04 (0.81, 1.33) | 1.81 (0.97, 2.13) | 0.13 |
| T (30) | |||||
| rs4713902 | T (70) | 1.0 | 0.69 (0.55, 0.88) | 0.47 (0.30, 0.74) | 0.001 |
| C (30) | |||||
| rs6912833 | T (73) | 1.0 | 0.80 (0.58, 1.10) | 0.77 (0.52, 1.15) | 0.36 |
| A (27) | |||||
| rs9380525 | C (68) | 1.0 | 0.73 (0.54, 0.97) | 0.69 (0.48, 1.01) | 0.09 |
| G (32) | |||||
Abbreviation: CI, confidence interval.
a
Odds ratios are calculated with respect to the reference group (the homozygous major allele for each marker). Odds ratios > 1.0 indicate that the genotype under examination (homozygous minor allele or heterozygous) is associated with higher risk. Odds ratios <1 indicate that the homozygous major allele is associated with higher risk.
b
Robust P-values are estimates of the overall trend for the data as calculated by the gtrr function using robust variance estimates.