Table 4.
Univariate analysis for overall survival.
| P-value | Hazard Ratio | 95% CI | |
|---|---|---|---|
| Methylation Markers | |||
| Any positive (EDNRB/DCC/P16) | 0.63 | 1.35 | [0.41, 4.43] |
| Other risk factors | |||
| Gender (Male vs. Female) | 0.74 | 1.15 | [0.52, 2.54] |
| Smoking status – continuous for at least 1 year (Yes vs. No) | 0.35 | 1.75 | [0.79, 3.88] |
| Overall Stage | 0.77 | ||
| 1 | ref | ||
| 2 | 1.61 | [0.36, 7.32] | |
| 3 | 1.15 | [0.23, 5.70] | |
| 4 | 1.75 | [0.52, 5.91] | |
| HPV (positive vs. negative) | 0.01 | 0.38 | [0.17, 0.84] |
| Primary site | 0.0003 | ||
| Oral cavity | reference | ||
| Oropharynx | 0.11 | [0.02, 0.50] | |
| Larynx | 0.36 | [0.08, 1.71] | |
| Unknown primary | 0 | - | |
| T-classification | <0.0001 | ||
| 1 | reference | ||
| 2 | 3.58 | [1.07, 11.97] | |
| 3 | 3.71 | [1.11, 12.37] | |
| 4 | 10.97 | [3.56, 33.82] | |
| Tx | 0.73 | [0.08, 6.67] | |
| N-classification | 0.7 | ||
| 0 | reference | ||
| 1 | 1.44 | [0.40, 5.17] | |
| 2A | 0.75 | [0.17, 3.39] | |
| 2B | 0.84 | [0.38, 1.85] | |
| 2C | 1.65 | [0.58, 4.73] | |