Table 1. Activation state-dependent recruitment of microtubule plus-end tracking proteins (+TIPs) to integrin complexes.
| Gene name | Protein name | Alias(es) | Fold enrichment (active/inactive) |
|---|---|---|---|
| ARHGEF2 | Rho/rac guanine nucleotide exchange factor 2 | GEF-H1 | 4.3 |
| BCAS2 | Pre-mRNA-splicing factor SPF27 | DAM1 | 1.9 |
| CDK5RAP2 | CDK5 regulatory subunit-associated protein 2 | CEP215 | U |
| CKAP5 | Cytoskeleton-associated protein 5 | Ch-TOG, XMAP215 | 3.4 |
| CLASP1 | Cytoplasmic linker-associated protein 1 | CLIP-associating protein 1, hOrbit1 | 5.1 |
| CLASP2 | Cytoplasmic linker-associated protein 2 | CLIP-associating protein 2, hOrbit2 | U |
| DCTN1 | Dynactin subunit 1 | p150-glued | 1.6 |
| DIAPH1 | Protein diaphanous homologue 1 | DRF1, mDia | 2.5 |
| DST | Dystonin | BPA | U |
| DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 | — | 3.1 |
| KIF18B | Kinesin-like protein KIF18B | — | U |
| KIF2C | Kinesin-like protein KIF2C | MCAK | 1.4 |
| MACF1 | Microtubule-actin crosslinking factor 1 | ABP620, ACF7 | 8.0 |
| MAPRE1 | Microtubule-associated protein RP/EB family member 1 | EB1 | 1.7 |
| MAPRE2 | Microtubule-associated protein RP/EB family member 2 | EB2 | 3.6 |
U, unique to active integrin adhesion complexes.
All +TIPs identified in adhesion complexes by MS are displayed. Proteins were classified as +TIP family members according to Gene Ontology assignment (GO:0051010, microtubule plus end binding; GO:0035371, microtubule plus end) or as described24,70. Non-identified +TIPs: APC, CLIP1, KIF17, KIF2B, KNSTRN, MAPRE3, MLPH, MTUS2, MYO5A, NAV1, PAFAH1B1, PSRC1, SLAIN2, SPAG5, SRCIN1, STIM1.