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. 2014 Jul 30;87(2):359–369. doi: 10.1038/ki.2014.274

Figure 3.

Figure 3

Effect of Ang(1–7) and valsartan treatment on the expression of collagen and cytokines in eight groups of rats. (a) Representative immunostaining of collagen IV, tumor growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), proliferating cell nuclear antigen (PCNA), and macrophages. (b) Quantitative analysis of collagen IV expression. (c) Quantitative analysis of TGF-β1 expression. (d) Quantitative analysis of VEGF expression. (e) Quantitative analysis of PCNA staining. Bar=50 μm. *P<0.05 vs. the control group; #P<0.05 vs. the no-treatment group; §P<0.05 vs. the valsartan group. NT: no treatment; S-Ang(1–7): small-dose Ang(1–7); M-Ang(1–7): moderate-dose Ang(1–7); L-Ang(1–7): large-dose Ang(1–7); L+V: large-dose Ang(1–7)+valsartan; L+A779: large-dose Ang(1–7)+ A779.