Figure 2.

Conformational changes upon ATP/PIP₂ binding measured by interdomain distances as observed in MD simulations of the three states of FK-FAK. (a) Distance distribution between the residues where FRET labels were inserted in the FERM and kinase domain (Fig. 1b). (b) Distance distribution between the centers of mass of the FERM F1 domain and the kinase N-lobe. (c) Average and deviations of the COM distance between the F1 lobe and the kinase N-lobe (yellow), the FRET distance (blue), and the COM distance between the FERM F2 subdomain and the kinase C-lobe (pink). To see this figure in color, go online.