Skip to main content
. 2015 Feb 3;108(3):666–677. doi: 10.1016/j.bpj.2014.10.075

Figure 1.

Figure 1

Electron microscopy pictures of transfected COP5 cells. (A, B, and D–F) Cells transfected with: langerinWT gene (A and B), langerinF241L gene (D and E), and langerinW264R gene (F). (C) Cells not transfected. The characteristic BG structure is shown in (A and B). Arrows point to CMS (observed with langerinWT) or superimposed and thickened membranes (observed with langerinF241L). Comparison of (B) with (E) shows the structural modification of CMS caused by the F241L mutation (substitution of the double layers with an inner striation with short, curved, and irregularly thickened double layers without inner electron-dense bodies), whereas panel (F) shows the loss of CMS with the W264R mutation.