Figure 3.

3D reconstruction of a control intercalated disc. (A) Projections (plicae) extend from both surfaces of the ICD (black arrows). (B) The ICD has an undulating surface projecting into the cardiac myocytes. The dashed arrows indicate a nexus domain that runs along the long axis of the disc. (Dashed line is the position of the clip plane used to generate the image in C.) (C) The interplicate (nexus) domain forms an almost vertical wall in this orientation and is exposed to both adjacent cardiac myocytes. Scale bar = 2 μm. Figure insets: direction of view (red arrow) indicators, the disc shape represents the ICD and position of the clipping plane is shown in cyan. To see this figure in color, go online.