Figure 5.
Lumped parameter model of OHC under the experimental conditions. (A) Schematic showing circuit and parameters of current measuring and voltage stimulating pipettes. Model was evaluated first under perforated patch (condition 1) and then under whole-cell (condition 2). See Materials and Methods for details. Right pipette is stimulating pipette. Parameters are taken from actual biophysical data given in Results. (B) With biophysical measures obtained under perforated patch and whole-cell condition, no differences in taus are observed. (C and D) Neither Rsh nor Rsp affects the evoked current time constants. However, interelectrode resistance has a profound effect on them, producing results similar to the biophysical data, indicating that this resistance must have changed upon entry into whole-cell mode. To see this figure in color, go online.