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. 2015 Feb 3;108(3):540–556. doi: 10.1016/j.bpj.2014.12.016

Figure 4.

Figure 4

Application of iHMM to single-molecule time series. (Top) Electrophysiological recording of a patch containing multiple channels and downward current deflections indicate channel opening events. (Middle) Traces from single-molecule FRET. (Bottom) Traces from single-molecule photobleaching. In each case, the data points are colored corresponding to the hidden state from which they are likely drawn. Algorithm parameters: α = 1 and γ = 1.