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. 2015 Jan 22;2015:916936. doi: 10.1155/2015/916936

Figure 3.

Figure 3

Functional study of Tim-3/PD-1 expression patterns on T cells. (a) PBMCs from HIV-infected patients (n = 4) were stimulated with TCR (anti-CD3/CD28) for 3 days, and IL-2 and IFN-γ production by T cells were detected. Distributions of Tim-3/PD-1 expression patterns on IFN-γ- and IL-2-producing T cells are indicated. (b) Statistical analysis of the distribution of differential Tim-3/PD-1 expression patterns on the IFN-γ- and IL-2-producing T cells (* P < 0.05). (c) PBMCs from HIV-infected patients were stimulated with anti-CD3 and anti-CD28 (n = 4) antibodies or HIV gag peptides (n = 8) with or without blocking antibodies (anti-Tim-3 and PD-1). IFN-γ and IL-2 production by CD4+ and CD8+ T cells before and after the anti-Tim-3/PD-1 blockade were compared (* P < 0.05).