Table 2. Possible post-vaccine side effects and contraindications in vaccinees for the Russian vaccines against the EDPs.

Diseases	Possible side effects, duration	Contraindications
		Typical	Specific
Plague	Local: 1–2 days after immunization—edema, hyperaemia, skin vesicular eruption at the site of inoculation Systemic: 1–3 days after immunization—malaise, headache, increased body temperature up to 37.5 °C, in 1% vaccinees—up to 39 °C in some	Acute infectious and noninfectious diseases; systemic connective-tissue diseases; malignant neoplasms; immunodeficiency; allergy and hypersensitivity	None
Anthrax	Did not produce serious/pronounced local or systemic adverse effects in vaccinees		Dermatoses and endocrine diseases
Tularemia	Local: hyperemia & edema (d 1–15 mm) 4–10 days post injection, produced by each vaccination by cutaneous route; sometimes a short-term swelling and painfulness of regional lymph nodes; mildly pronounced/marked hyperaemia and edema (d up to 40 mm) Systemic: none		Individuals who have had tularemia and positive serological or skin tests for tularemia
Cholera	Local: slight discomfort in the epigastric region after 1–2 h post immunization; borborygmi and mushy stools that pass quickly and do not require treatment Systemic: none		Gastrointestinal dysfunction
Glanders	Local: none reported Systemic: none reported		None
Brucellosis Prevention of brucellosis in humans	Local: 1–2 days after immunization—hyperaemia, skin vesicular eruption or infiltrate at the site of inoculation Systemic: 1–3 days after immunization in 1%–2% vaccines—malaise, headache, increased body temperature up to 37.5–38 °C		Recent brucellosis Positive serological and skin tests for brucellosis
Therapeutic	Local: none Systemic: increased body temperature up to 37.5–39.5 °C, light fever exacerbates pain in the lesions		Decompensated cardiovascular diseases; hemorrhagic diathesis; organic lesions of the central nervous system; chronic diseases, acute flare-ups

Abbreviation: d, diameter.