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. 2014 Nov 25;199(2):543–554. doi: 10.1534/genetics.114.171819

Table 1. Predicted genes found in fine mapped regions of hms1 and hms2.

Locus	Gene name^a	Gene annotation^a	Predicted functional role^b	Sterility phenotype in Arabidopsis?
hms1	Migut.F01605 and Migut.F01606	Skp1 family	Cell cycle regulation, component of SCF ubiquitin–ligase complex^c	Arabidopsis Skp1 homolog (ASK1) mutant causes male sterility via defects in male meiosis^d
	Migut.F01607	Iron–sulfur cluster biosynthesis	Iron–sulfur cluster binding, structural molecule activity
	Migut.F01608	4′-phosphopantetheinyl transferase superfamily	Involved in metabolic processes, macromolecule biosynthesis
	Migut.F01609	None
	Migut.F01610	Leucine rich repeat (LRR)	Kinase activity, signal transduction; diverse roles in plant development and disease resistance^e	Mutations in EMS1/EXS (1 of >200 LRR genes in Arabidopsis) causes male sterility when microsporocytes do not undergo proper cytokinesis^f
	Migut.F01611	PPR repeat	Organellar RNA processing, embryonic development^g	Some members of this large gene family (450 in Arabidopsis) are involved in fertility restoration of CMS plants^h
	Migut.F01612	F-box	Component of SCF ubiquitin–ligase complex, targets specific proteins for degradation	Among this large gene family (>600 in Arabidopsis), COI1 mutants are male sterileⁱ, FBL17 mutants inhibit male germline proliferation^j, the rice hybrid sterility gene SaF encodes an F-box protein^k
	Migut.F01613	None
	Migut.F01614	Yip1 domain; Golgi membrane protein	Involved in the trans-Golgi network^l
	Migut.F01615	Amino acid kinase family; gamma-glutamyl kinase	Amino acid biosynthesis
hms2	Migut.M00294	Protein kinase domain; cdc2-related protein kinase	Cyclin-dependent kinase (CDK)-like protein^m, cell cycle regulation	Arabidopsis cdc2 mutant (CDKA;1) is male sterile because it fails to progress through the second mitosis in male gametogenesisⁿ
	Migut.M00295	Cellulase (glycosyl hydrolase family 5)	Involved in carbohydrate metabolism, hydrolase activity
	Migut.M00296	None
	Migut.M00297	RNA polymerase Rpb2	Encodes a subunit of DNA-dependent RNA polymerase II
	Migut.M00298	GH3 auxin-responsive promoter	Involved in red light-specific hypocotyl elongation

^a

http://www.phytozome.net.

^b

Unless a citation is provided, functional descriptions are taken from TAIR (arabidopsis.org) for the gene’s closest Arabidopsis thaliana BLAST hit.

^c

Bai et al. 1996; Yang et al. 2012.

^d

Yang et al. 1999.

^e

Diévart and Clark 2004.

^f

Canales et al. 2002; Zhao et al. 2002.

^g

Saha et al. 2007.

^h

Barr and Fishman 2010; Barkan and Small 2014.

ⁱ

Xie et al. 1999.

^j

Kim et al. 2008; Gusti et al. 2009.

^k

Long et al. 2008.

^l

Drakakaki et al. 2012.

^m

Menges et al. 2005.

ⁿ

Nowack et al. 2005; Iwakawa et al. 2006.