Table 4. The percentages of viable cells in the biofilms of the six strains treated with H2-81 and H2-38.
| Strainsa | |||||||
|---|---|---|---|---|---|---|---|
| Treatmenta | MRSA 1000234 | MRSA 916054 | MSSA 1815 | MRSE 1020081 | MRSE 915296 | MSSE 914111 | |
| Viable cells/total (%) |
H2-81 | 1.6 | 7.8 | 8.2 | 11.6 | 7.9 | 8.9 |
| H2-38 | 3.5 | 10.4 | 7.5 | 16.2 | 8.6 | 12.3 | |
| Vancomycin | 80.1 | 75.6 | 77.8 | 75.4 | 80.8 | 79.6 | |
| DMSOb |
92.4 |
89.1 |
88.5 |
91.8 |
91.4 |
93.6 |
|
| MIC (μM) | H2-81 | 1.5 | 12.5 | 1.5 | 3.1 | 3.1 | 1.5 |
| H2-38 | 1.5 | 12.5 | 1.5 | 6.3 | 3.1 | 1.5 | |
a
The six strains were selected randomly from 19 strong biofilm producers (MRSA 1000234, MRSA 916054, MSSA 1815, MRSE 1020081, MRSE 915296 and MSSE 914111).
b
Stock solutions of the compounds were prepared in 0.1% DMSO. Biofilms treated with 0.1% DMSO were used as the negative control.