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. 2015 Feb 5;5:8269. doi: 10.1038/srep08269

Figure 7. Improvement of locomotion after SCI in mice lacking CRMP4.

Figure 7

(a) Functional analysis of open field locomotor activity by BMS scoring up to 28 days after near-complete transection of spinal cord in Crmp4+/+ and Crmp4−/− mice. Note that locomotor recovery in Crmp4−/− mice is significant from early stages post-SCI (n = 7 mice for each genotype). ***, P < 0.001, compared with scores in Crmp4+/+ mice. Statistical analysis was performed using the two-way ANOVA test. Data are mean ± S.E.M. (b) Photograph of a Crmp4+/+ mouse at 4 weeks after SCI demonstrating inability to move with hindlimbs. (c, d) Examples of Crmp4−/− mouse bearing its body weight at 4 weeks after SCI (c) and sweeping with the hindlimb at 1 week after SCI (d).