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. 2015 Feb 5;5:8278. doi: 10.1038/srep08278

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(a) SPAG9(L) and (b) RUNDC1(C) mutations in familial glioma pedigrees. Individuals with glioma are shown as filled. Individuals with other cancers are shown as half-filled. Disease and age in years (y) at first diagnosis is given underneath the symbol, current age or age at death (+) above it. Glioma type is shown (AA, anaplastic astroctyoma; Astro, astrocytoma; GBM, glioblastoma multiforme). Other cancers in the pedigree are shown (OvC, ovarian cancer; Mel, melanoma;TesC, testicular cancer; Lym, lymphoma). Carriers of SPAG9 (a) and RUNDC1 (b) mutations are shown with their specific mutation, whereas individuals who tested negative for the mutation in the specific pedigree are depicted as wild-type (WT).