Table 3.
Rates of death, listing for transplant, and renal transplantation in patients with end-stage lupus nephritis (n=16,434 [98.7%]) and an equal number of matched control patients with ESRD from other causes
| Variable | Death | Listing for Transplant | Transplantation | |||
|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | |
| All | 7.9 (7.8 to 8.1) | 7.9 (7.8 to 8.1)a | 14.6 (14.3 to 15) | 10.8 (10.5 to 11.1) | 7.9 (7.7 to 8.1) | 6.8 (6.6 to 7) |
| Year of first RRT | ||||||
| 1995–2000 | 7.8 (7.5 to 8.1) | 7.5 (7.2 to 7.7)a | 12.2 (11.7 to 12.7) | 9.6 (9.2 to 10) | 8.5 (8.2 to 8.9) | 7.3 (7 to 7.6) |
| 2000–2005 | 8.0 (7.7 to 8.3) | 8.4 (8 to 8.7)a | 14.9 (14.3 to 15.5) | 10.7 (10.2 to 11.2) | 7.7 (7.4 to 8.1) | 6.8 (6.5 to 7.2) |
| 2006–2010 | 8.0 (7.8 to 8.2) | 8.0 (7.8 to 8.2)a | 14.9 (14.6 to 15.3) | 10.9 (10.6 to 11.2) | 7.9 (7.6 to 8.1) | 6.7 (6.5 to 6.9) |
| Age | ||||||
| <20 yr | 5.1 (4.6 to 5.7) | 2.3 (2 to 2.6) | 19.8 (18.3 to 21.5) | 18.4 (17 to 19.9)a | 11.3 (10.3 to 12.3) | 16 (14.8 to 17.3) |
| 20–29 yr | 4.8 (4.5 to 5.1) | 4.2 (4 to 4.5)c | 17.4 (16.6 to 18.3) | 14.7 (14 to 15.5) | 9.6 (9.1 to 10.2) | 9.4 (8.9 to 9.9)a |
| 30–44 yr | 6.0 (5.8 to 6.3) | 6.9 (6.6 to 7.2) | 16.4 (15.8 to 17.0) | 11.0 (10.5 to 11.5) | 8.1 (7.8 to 8.5) | 6.3 (6 to 6.6) |
| 45–64 yr | 11.8 (11.3 to 12.3) | 13.1 (12.6 to 13.6) | 11.5 (10.9 to 12.1) | 7.3 (6.9 to 7.8) | 6.4 (6.0 to 6.8) | 3.8 (3.5 to 4.1) |
| ≥65 yr | 30.1 (28.3 to 32) | 30 (28.2 to 31.9)a | 2.8 (2.3 to 3.5) | 1.6 (1.2 to 2.2)c | 1.7 (1.3 to 2.2) | 0.9 (0.6 to 1.3)c |
| Sex | ||||||
| Male | 8.4 (7.9 to 8.8) | 7.4 (7 to 7.8)c | 14.2 (13.4 to 15.1) | 11.5 (10.8 to 12.2) | 8.6 (8.1 to 9.2) | 7.8 (7.3 to 8.4)a |
| Female | 7.8 (7.6 to 8.1) | 8.1 (7.9 to 8.3)a | 14.7 (14.3 to 15.1) | 10.7 (10.4 to 11) | 7.7 (7.5 to 8) | 6.5 (6.3 to 6.8) |
| Race/ethnicity | ||||||
| Non-Hispanic white | 9.1 (8.7 to 9.4) | 10 (9.6 to 10.4) | 12.1 (11.5 to 12.7) | 9.8 (9.3 to 10.3) | 10.4 (9.9 to 11) | 9.2 (8.8 to 9.8)c |
| Non-Hispanic African American | 8.8 (8.5 to 9.1) | 8.4 (8.2 to 8.7)a | 15.2 (14.7 to 15.8) | 9.8 (9.4 to 10.2) | 6.3 (6.0 to 6.6) | 5 (4.8 to 5.3) |
| Hispanic | 5.1 (4.7 to 5.4) | 4.8 (4.5 to 5.2)a | 16.1 (15.2 to 17) | 13.7 (13 to 14.6) | 8.6 (8.0 to 9.2) | 8.2 (7.6 to 8.7)a |
| Other | 5.0 (4.5 to 5.6) | 4.4 (3.9 to 4.9)a | 17.8 (16.3 to 19.5) | 16.9 (15.5 to 18.6)a | 8.7 (7.8 to 9.6) | 8.5 (7.7 to 9.5)a |
Rates are per 100 person-years, with 95% confidence intervals in parentheses. Causes of ESRD in controls were diabetes mellitus type 2, 26%; unspecified renal failure, 22.1%; diabetes mellitus type 1, 9.6%; FSGS, 6.6%; GN (histologically not examined), 6.5%; other causes, 29.2%. Factors used for matching were year of inception of RRT, age (in 1-year intervals), sex, race, and ethnicity. P<0.001 unless otherwise stated.
a
P≥0.05.
b
0.001=P<0.01.