Table 1.
Relevant proteins expressed in kidney intercalated cells
| Intercalated Cell Type Protein Expressed | Type A | Type B | Non-A, Non-B |
|---|---|---|---|
| Carbonic anhydrase II: catalyzes the reversible hydration of CO2 to bicarbonate and water | Apical | Cytoplasmic | Cytoplasmic |
| H+-ATPase: pumps H+ across the (plasma) membrane, and into the extracellular space | Apicala | Basolaterala | Apical and diffuse vesiculara |
| AE1 (Slc4a1): anion exchanger 1, exchanges a Cl- for a bicarbonate | Basolaterala | ||
| Pendrin (Slc26a4): exchanges a Cl- for a bicarbonate | Apicala | Apicala | |
| H+/K+-ATPase: exchanges an H+ for a K+ at the expense of ATP | Apical | Apical? | |
| AE4 (Slc4a4): anion exchanger 4, exchanges a Cl- for (n) bicarbonate | Basolateral | ||
| RhBG: Rh B glycoprotein, ammonia transporter | Basolateral | Basolateral | |
| RhCG: Rh C Glycoprotein, ammonia transporter | Apical | Apical | |
| NDCBE (Slc4a8): Na+-driven Cl−/bicarbonate exchanger | Apical | ||
| A11 (Slc26a11): electrogenic Cl− transporter and Cl−/HCO3- anion exchanger | Apical | ||
| NKCC1: Na+-K+-2Cl− cotransporter | Basolateral | ||
| BK channel or Maxi-K: K+ secretion | Apical |
Adapted from reference 36. BK, big potassium.
a
The differential localization patterns pertaining to the transport proteins identify a combination of key markers that aid in the classification of the different intercalated cell subtypes.