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. 2014 Dec 23;106(1):78–85. doi: 10.1111/cas.12574

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Downregulation of SRC mitigates radiation-enhanced resistance of breast cancer cells to anticancer agents. Quantification of cell death by FACS analysis using propidium iodide staining. MCF7 breast cancer cells transfected with siRNA targeting SRC (si-SRC) or scrambled control siRNA (si-Cont) were exposed to fractionated radiation and then treated with cisplatin (50 μM) (a), etoposide (b), paclitaxel (500 nM) (c), or exposure to ionizing radiation (10 Gy) (d). **P < 0.01. Cont, control; N.S., Not significant.