Table V. STIP1 Haplotype Association with % Change in FEV1.
4 weeks % change FEV1 Global** p = 0.012 |
8 weeks % change FEV1 Global** p = 0.07 |
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rs7941773 | rs2845597 | rs4980524 | rs6591838 | rs2282490 | rs2236647 | rs2236648 | rs1011219 | Haplotype Frequency |
Hap-Score | p-value | Hap-Score | p-value | |
6 | C | G | A | A | T | C | C | G | 0.56 | −1.93 | 0.053 | −1.96 | 0.05 |
5 | T | A | C | G | T | T | T | A | 0.11 | 0.06 | 0.95 | −0.05 | 0.96 |
3 | C | A | C | A | C | T | T | G | 0.19 | 0.03 | 0.98 | −0.02 | 0.98 |
1 | C | G | A | A | T | T | C | G | 0.03 | −0.02 | 0.98 | 0.14 | 0.89 |
4 | C | A | C | G | T | T | T | G | 0.03 | −0.36 | 0.71 | 0.21 | 0.84 |
2 | C | G | C | G | T | T | T | G | 0.07 | 2.29 | 0.02 | 2.93 | 0.0034 |
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C | G | A | 0.60 | −1.76 | 0.08 | −1.87 | 0.06 | ||||||
4A | C | A | C | 0.22 | −0.08 | 0.93 | −0.18 | 0.86 | |||||
T | A | C | 0.11 | 0.49 | 0.62 | 0.15 | 0.88 | ||||||
C | G | C | 0.07 | 2.86 | 0.004 | 3.67 | 0.0002 | ||||||
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G | A | A | 0.60 | −1.77 | 0.08 | −1.87 | 0.06 | ||||||
4B | A | C | A | 0.19 | −0.03 | 0.97 | −0.21 | 0.84 | |||||
A | C | G | 0.14 | 0.41 | 0.67 | 0.19 | 0.85 | ||||||
G | C | G | 0.07 | 2.86 | 0.004 | 3.64 | 0.0003 | ||||||
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A | A | T | 0.60 | −1.78 | 0.08 | −1.87 | 0.06 | ||||||
4C | C | A | C | 0.19 | 0.02 | 0.98 | −0.25 | 0.80 | |||||
C | G | T | 0.21 | 2.04 | 0.04 | 2.50 | 0.01 | ||||||
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A | T | C | 0.57 | −1.67 | 0.09 | −1.77 | 0.08 | ||||||
4D | A | C | T | 0.19 | −0.01 | 0.99 | −0.34 | 0.73 | |||||
A | T | T | 0.03 | −0.08 | 0.93 | 0.27 | 0.79 | ||||||
G | T | T | 0.21 | 2.02 | 0.044 | 2.34 | 0.02 | ||||||
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T | C | C | 0.56 | −1.90 | 0.06 | −1.93 | 0.054 | ||||||
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4E | C | T | T | 0.19 | 0.02 | 0.98 | −0.34 | 0.73 | |||||
T | T | C | 0.03 | 0.93 | 0.35 | 1.19 | 0.23 | ||||||
T | T | T | 0.21 | 1.56 | 0.12 | 1.93 | 0.054 | ||||||
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C | C | G | 0.56 | −1.91 | 0.056 | −1.94 | 0.053 | ||||||
4F | T | T | A | 0.11 | 0.04 | 0.96 | −0.38 | 0.70 | |||||
T | C | G | 0.03 | 0.92 | 0.36 | 1.19 | 0.24 | ||||||
T | T | G | 0.28 | 1.43 | 0.15 | 1.72 | 0.09 |
Trends towards significance in italics.
Based on Hap-Score comparisons between six haplotypes.