Table 4.
p53 mutations | Total no. | HPV-positive | Univariate analysis† |
Multivariate analysis‡,§ |
||||||
---|---|---|---|---|---|---|---|---|---|---|
No. (%) | Odds ratio | 95% CI | P-value | Odds ratio | 95% CI | P-value | ||||
Oropharyngeal carcinoma | p53 status | Wild-type | 57 | 28 (49.1) | Reference | Reference | ||||
Mutant | 25 | 2 (8.0) | 0.09 | 0.01–0.3 | <0.001 | 0.1 | 0.02–0.5 | 0.005 | ||
Mutation category | Wild-type | 57 | 28 (49.1) | Reference | ||||||
Non-disruptive | 15 | 2 (13.3) | 0.2 | 0.02–0.6 | 0.008 | |||||
Disruptive | 10 | 0 (0.0) | 0.05 | 0.003–0.9 | <0.001 | |||||
Non-oropharyngeal carcinoma | p53 status | Wild-type | 117 | 5 (4.3) | Reference | |||||
Mutant | 84 | 4 (4.8) | 1.1 | 0.3–4.4 | 0.868 | |||||
Mutation category | Wild-type | 117 | 5 (4.3) | Reference | ||||||
Non-disruptive | 61 | 4 (6.6) | 1.6 | 0.4–6.2 | 0.516 | |||||
Disruptive | 23 | 0 (0.0) | 0.4 | 0.02–7.4 | 0.176 |
Univariate analysis was carried out using the logistic regression model for p53 status and by the Clopper–Pearson method for mutation category.
Multivariate analysis was carried out using the forward stepwise logistic regression model.
Ajusted for cigarette smoking and alcohol drinking. CI, confidence interval.