Table 4.

Relationship between human papillomavirus (HPV) status and p53 mutations in head and neck squamous cell carcinomas (n = 283)

	p53 mutations		Total no.	HPV-positive	Univariate analysis†			Multivariate analysis‡,§
				No. (%)	Odds ratio	95% CI	P-value	Odds ratio	95% CI	P-value
Oropharyngeal carcinoma	p53 status	Wild-type	57	28 (49.1)	Reference			Reference
		Mutant	25	2 (8.0)	0.09	0.01–0.3	<0.001	0.1	0.02–0.5	0.005
	Mutation category	Wild-type	57	28 (49.1)	Reference
		Non-disruptive	15	2 (13.3)	0.2	0.02–0.6	0.008
		Disruptive	10	0 (0.0)	0.05	0.003–0.9	<0.001
Non-oropharyngeal carcinoma	p53 status	Wild-type	117	5 (4.3)	Reference
		Mutant	84	4 (4.8)	1.1	0.3–4.4	0.868
	Mutation category	Wild-type	117	5 (4.3)	Reference
		Non-disruptive	61	4 (6.6)	1.6	0.4–6.2	0.516
		Disruptive	23	0 (0.0)	0.4	0.02–7.4	0.176

^†Univariate analysis was carried out using the logistic regression model for p53 status and by the Clopper–Pearson method for mutation category.

^‡Multivariate analysis was carried out using the forward stepwise logistic regression model.

^§Ajusted for cigarette smoking and alcohol drinking. CI, confidence interval.