Table 2.
Incidence, incidence rate ratio and adjusted hazard ratio of cancer by sex, age and comorbidities compared between cohorts with and without early onset cataracts
| Early onset cataract |
||||||||
|---|---|---|---|---|---|---|---|---|
| No |
Yes |
Compared to without early onset cataract |
||||||
| Event | PY | Rate‡ | Event | PY | Rate‡ | IRR§ (95% CI) | Adjusted HR† (95% CI) | |
| All | 89 | 24 207 | 3.68 | 48 | 5953 | 8.06 | 2.19 (1.88, 2.56)*** | 2.13 (1.48, 3.07)*** |
| Sex | ||||||||
| F | 43 | 12 316 | 3.49 | 27 | 3051 | 8.85 | 2.54 (2.04, 3.15)*** | 2.73 (1.67, 4.47)*** |
| M | 46 | 11 891 | 3.87 | 21 | 2903 | 7.23 | 1.87 (1.50, 2.33)*** | 1.64 (0.95, 2.83) |
| Age | ||||||||
| 20–35 | 2 | 2243 | 0.89 | 1 | 583 | 1.72 | 1.92 (1.09, 3.40)* | 1.54 (0.13, 18.3) |
| 36–45 | 18 | 5713 | 3.15 | 10 | 1384 | 7.23 | 2.29 (1.68, 3.14)*** | 2.00 (0.88, 4.53) |
| 46–55 | 69 | 16 251 | 4.25 | 37 | 3986 | 9.28 | 2.19 (1.81, 2.63)*** | 2.14 (1.41, 3.25)*** |
| Comorbidity | ||||||||
| Diabetes | ||||||||
| No | 82 | 22 356 | 3.67 | 34 | 4570 | 7.44 | 2.03 (1.71, 2.41)*** | 2.02 (1.35, 3.03)*** |
| Yes | 7 | 1851 | 3.78 | 14 | 1383 | 10.12 | 2.68 (1.69, 4.24)*** | 2.71 (1.08, 6.82)* |
| Hypertension | ||||||||
| No | 63 | 20 171 | 3.12 | 35 | 4253 | 8.23 | 2.64 (2.22, 3.13)*** | 2.68 (1.76, 4.08)*** |
| Yes | 26 | 4036 | 6.44 | 13 | 1701 | 7.64 | 1.19 (0.84, 1.67) | 1.19 (0.59, 2.38) |
| Hyperlipidemia | ||||||||
| No | 78 | 20 976 | 3.72 | 34 | 4387 | 7.75 | 2.08 (1.75, 2.48)*** | 2.06 (1.37, 3.12)*** |
| Yes | 11 | 3231 | 3.40 | 14 | 1567 | 8.93 | 2.62 (1.82, 3.79)*** | 2.56 (1.13, 5.78)* |
| Stroke | ||||||||
| No | 87 | 23 978 | 3.63 | 47 | 5853 | 8.03 | 2.21 (1.89, 2.59)*** | 2.14 (1.48, 3.10)*** |
| Yes | 2 | 229 | 8.74 | 1 | 100 | 9.97 | 1.14 (0.36, 3.64) | 0.89 |
| Ischemic heart disease | ||||||||
| No | 79 | 22 740 | 3.47 | 39 | 5342 | 7.30 | 2.10 (1.78, 2.47)*** | 2.16 (1.46, 3.20)*** |
| Yes | 10 | 1466 | 6.82 | 9 | 611 | 14.7 | 2.16 (1.29, 3.63)** | 2.08 (0.79, 5.49) |
| COPD | ||||||||
| No | 75 | 19 972 | 3.76 | 33 | 4319 | 7.64 | 2.03 (1.70, 2.43)*** | 1.95 (1.27, 2.98)** |
| Yes | 15 | 4234 | 3.31 | 15 | 1635 | 9.18 | 2.78 (1.98, 3.89)*** | 2.73 (1.29, 5.77)** |
| Asthma | ||||||||
| No | 87 | 23 461 | 3.71 | 47 | 5683 | 8.27 | 2.23 (1.91, 2.61)*** | 2.15 (1.49, 3.10)*** |
| Yes | 2 | 746 | 2.68 | 1 | 270 | 3.70 | 1.38 (0.56, 3.41) | 2.24 (0.12, 40.5) |
| Alcohol-related illness | ||||||||
| No | 84 | 23 823 | 3.53 | 46 | 5797 | 7.93 | 2.25 (1.93, 2.63)*** | 2.24 (1.54, 3.26)*** |
| Yes | 5 | 383 | 13.0 | 2 | 156 | 12.8 | 0.98 (0.39, 2.48) | 0.63 (0.10, 4.11) |
*
P < 0.05
**
P < 0.01
***
P < 0.001.
†
Adjusted HR: multivariable analysis including sex, age and comorbidities of diabetes, hypertension, hyperlipidemia, stroke, ischemic heart disease, asthma, chronic obstructive pulmonary disease and alcohol-related illness.
‡
Rate, incidence rate, per 1000 person-years.
§
IRR, incidence rate ratio, per 1000 person-years. –, not available; COPD, chronic obstructive pulmonary disease; PY, person-years.