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. 2014 Mar 17;105(4):445–454. doi: 10.1111/cas.12364

Fig. 2.

Fig. 2

EX527-mediated inhibition of sirtuin 1 (SIRT1) activity suppresses pancreatic cancer cell proliferation. (a) EX527 inhibits deacetylase activity of SIRT1 in pancreatic cancer cells. PANC-1, BXPC-3, ASPC-1, and 293T (control) cells were exposed to EX527 (2 μM) for 48 h. Deacetylase activity of SIRT1 was measured by the Fluor de Lys assay. (b) Growth inhibitory effect of EX527 on pancreatic cancer cell lines but not 293T cells. PANC-1, BXPC-3, ASPC-1, and 293T cells were exposed to different concentrations of EX527 for 48 h, and MTT assay was used to determine cell viability. *P < 0.05 versus control group.