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. 2014 Mar 24;105(4):481–489. doi: 10.1111/cas.12378

Fig. 3.

Fig. 3

(a) Genome-wide frequency of the genomic imbalance in diffuse large B-cell lymphoma (DLBCL) subtypes: non-germinal center B-cell-like (GCB) group (26 cases) and GCB group (20 cases). Horizontal lines indicate 2213 BAC/PAC clones ordered from chromosomes 1 to 22 and X. Within each chromosome, clones are shown in order from the p telomere to the q telomere. Vertical lines indicate the frequency (%) of gains and losses. Non-GCB and GCB subtypes are shown to have different genomic imbalance characteristics. (b) Contrastive analysis of genomic gains of GCB and non-GCB subtypes with frequencies of >50%. Horizontal lines indicate BAC/PAC clones of genomic gains with high frequencies (>50%) in each subtype in order of increasing frequencies of gains in the GCB subtype. Vertical lines indicate the frequency (%) of gains. The figure shows that the frequencies of gains at specific loci in each subtype were different. (c) Contrastive analysis of genomic losses of GCB and non-GCB subtypes with frequencies of >40%. Horizontal lines indicate BAC/PAC clones of genomic losses with high frequencies (>40%) in each subtype in order of increasing frequency of losses in GCB samples. Vertical lines indicate the frequency (%) of losses. The frequencies of genomic losses with high frequencies (>40%) were different between the non-GCB and GCB subtypes.