Table 3.
Frequent regions of genomic imbalance in germinal center B-cell-like (GCB) or non-GCB diffuse large B-cell lymphoma (DLBCL)
| Gain |
Loss |
||||
|---|---|---|---|---|---|
| Chromosome band | GCB% (n/GCB) | Non-GCB% (n/Non-GCB) | Chromosome band | GCB% (n/GCB) | Non-GCB% (n/Non-GCB) |
| 11q24.3 | 0 (0/20) | 58 (15/26) | 1q43 | 25 (5/20) | 42 (11/26) |
| 3q13.2 | 5 (1/20) | 54 (14/26) | 8q24.23 | 30 (6/20) | 42 (11/26) |
| 7q22-7q31.1 | 5 (1/20) | 50 (13/26) | 10q25.1 | 30 (6/20) | 42 (11/26) |
| 11q24.3 | 15 (3/20) | 58 (15/26) | 1p36.23-31 | 35 (7/20) | 46 (12/26) |
| 1q23.3 | 25 (5/20) | 50 (13/26) | 1p36.13 | 35 (7/20) | 46 (12/26) |
| 12q22 | 25 (5/20) | 50 (13/26) | 8p21.3 | 35 (7/20) | 50 (13/26) |
| 12q21.33 | 30 (6/20) | 50 (13/26) | 15q11.2 | 35 (7/20) | 42 (11/26) |
| 3q23 | 45 (9/20) | 54 (14/26) | 1p36.32 | 40 (8/20) | 38 (10/26) |
| BCL2 | 50 (10/20) | 50 (13/26) | 6q22.33 | 40 (8/20) | 31 (8/26) |
| 7p21.1 | 55 (11/20) | 27 (7/26) | 6q27 | 40 (8/20) | 35 (9/26) |
| 7q21.2 | 55 (11/20) | 27 (7/26) | 16q21 | 40 (8/20) | 12 (3/26) |
| 7q34-7q35 | 55 (11/20) | 23 (6/26) | 16q23.3 | 40 (8/20) | 31 (8/26) |
| 12q24.31 | 55 (11/20) | 35 (9/26) | 6q27 | 40 (8/20) | 46 (12/26) |
| 7p14.2 | 60 (12/20) | 27 (7/26) | 4p15.31 | 45 (9/20) | 15 (4/26) |
| 7q22.1 | 60 (12/20) | 15 (4/26) | 6q16.3 | 45 (9/20) | 42 (11/26) |
| 7q22.3 | 60 (12/20) | 50 (13/26) | 16q12.1 | 45 (9/20) | 31 (8/26) |
| 7q31.1 | 60 (12/20) | 31 (8/26) | 6q16.3 | 45 (9/20) | 42 (11/26) |
| 7q31.2 | 65 (13/20) | 23 (6/26) | 2q14.3 | 50 (10/20) | 38 (10/26) |
| 6q23.2 | 50 (10/20) | 38 (10/26) | |||
| 6q26 | 50 (10/20) | 35 (9/26) | |||
| 16q | 50 (10/20) | 4 (1/26) | |||
| 16q12.2 | 55 (11/20) | 50 (13/26) | |||
Copy number change of X chromosome was excluded. n, case numbers in each sub group of DLBCL identified by immunostaining. %, percentage of positive cases in each sub group of DLBCL identified by immunostaining.