Table 4.
Frequent regions of genomic imbalances in each subgroup of germinal center B-cell-like (GCB) or non-GCB diffuse large B-cell lymphoma (DLBCL) identified by immunostaining
| (a) Frequent regions of genomic gains in each sub group of GCB DLBCL identified by immunostaining | |||||||
|---|---|---|---|---|---|---|---|
| GCB gain | |||||||
| CD10+ only |
BCL6+ only |
CD10+BCL6+ |
CD10+BCL6+MUM1+ |
||||
| Chromosome band | % (n/CD10+only) | Chromosome band | % (n/BCL6+ only) | Chromosome band | % (n/CD10+BCL6+) | Chromosome band | % (n/CD10+BCL6+MUM1+) |
| 7q34–7q35 | 75 (6/8) | 7q22.1, 7q22–7q31.1 | 83 (5/6) | 2p16.2 | 80 (4/5) | 1q21–1q25, 1q31–1q32, 1q41–1q44 | 100 (1/1) |
| 11q23.3 | 75 (6/8) | 2p14 | 67 (4/6) | 7q22–7q31.1 | 80 (4/5) | 2p12–2p16 | 100 (1/1) |
| 1q23.3 | 63 (5/8) | 3q29 | 67 (4/6) | 11p11.2, 11q13.4, 11q22.1, 11q22.3, | 80 (4/5) | 3q13.2 | 100 (1/1) |
| 2p16.1 | 63 (5/8) | 7p11–7p14, 7q21–7q31 | 67 (4/6) | 17q21.2, 17q24.1, | 80 (4/5) | 6p25.3 | 100 (1/1) |
| 3q28 | 63 (5/8) | 8q24.1 | 67 (4/6) | 1q23.3, 1q25.1 | 60 (3/5) | 6p21–6p25 | 100 (1/1) |
| 7q22.1, 7q22–7q31.1, 7q31.1 – 7q34 | 63 (5/8) | 12q13.12 | 67 (4/6) | 2p16.1, | 60 (3/5) | 7p21–7p22 | 100 (1/1) |
| 11q23.3, 11q23.3 | 63 (5/8) | BCL2 | 67 (4/6) | 3q23, 3q28 | 60 (3/5) | 7p11–7p15, 7q11.23–7q21.1, 7q22–7q31, 7q36 | 100 (1/1) |
| 6p21–6p23, 6q21 | 60 (3/5) | 8q12–8q13, 8q21–8q24 | 100 (1/1) | ||||
| 7p22.1, 7p14–7p15, 7q31.2, 7q34 | 60 (3/5) | 11p13 | 100 (1/1) | ||||
| 8q24.21 | 60 (3/5) | 12q22, 12q24 | 100 (1/1) | ||||
| 11p13, 11q13– 11q14, 11q21–11q23 | 60 (3/5) | 15q15.3 | 100 (1/1) | ||||
| 12q21, 12q24.31 | 60 (3/5) | 17q12, 17q21.2, 17q25.3 | 100 (1/1) | ||||
| 14q23 | 60 (3/5) | 18p11.32 | 100 (1/1) | ||||
| 15q23 | 60 (3/5) | 20q12, 20q13.2 | 100 (1/1) | ||||
| 16p13.3 | 60 (3/5) | 22q | 100 (1/1) | ||||
| 17q25.3 | 60 (3/5) | ||||||
| (b) Frequent regions of genomic losses in each subgroup of GCB DLBCL identified by immunostaining | |||||||
| GCB loss | |||||||
| CD10+ only |
BCL6+ only |
CD10+BCL6+ |
CD10+BCL6+MUM1+ |
||||
| Chromosome band | % (n/CD10+ only) | Chromosome band | % (n/BCL6+ only) | Chromosome band | % (n/CD10+BCL6+) | Chromosome band | % (n/CD10+BCL6+MUM1+) |
| 10q25.1 | 50 (4/8) | 4p15.31 | 83 (5/6) | 16q12, 16q22– 16q24 | 60 (3/5) | 1p36,1p35, 1p34.3 | 100 (1/1) |
| 6q16.3 | 50 (4/8) | 6q22.33 | 67 (4/6) | 18q12.2d | 60 (3/5) | 2q14.3, 2q35 | 100 (1/1) |
| 9p21.3 | 50 (4/8) | 1p36.32, 1p31.1, 1q43 | 67 (4/6) | 1p36.13 | 60 (3/5) | 3q27.2, 3q28, 3q29 | 100 (1/1) |
| 16q12.2 | 50 (4/8) | 3p12.1–p12.2 | 67 (4/6) | 2p24 | 60 (3/5) | 4q34.3 | 100 (1/1) |
| 16q24 | 50 (4/8) | 4q13.1 | 67 (4/6) | 2q14.3, 2q21– 2q24 | 60 (3/5) | 5p15.33 | 100 (1/1) |
| 6q23.2 | 67 (4/6) | 5p15.33 | 60 (3/5) | 6q14–6q16, 6q21–6q27 | 100 (1/1) | ||
| 8p22 | 67 (4/6) | 6q26, 6q27 | 60 (3/5) | 11q21, 11q22 | 100 (1/1) | ||
| 16p13.2, 16q12, 16q23.3 | 67 (4/6) | 8p21.3, 8q24.23 | 60 (3/5) | 13q13.1–13q13.3, 13q14 | 100 (1/1) | ||
| 16q12, 16q21 | 100 (1/1) | ||||||
| 17q25.3 | 100 (1/1) | ||||||
| 22q13 | 100 (1/1) | ||||||
| (c) Frequent regions of genomic gains in each subgroup of Non-GCB DLBCL identified by immunostaining | |||||||
| Non-GCB gain | |||||||
| MUM1+ only |
BCL6+MUM1+ |
||||||
| Chromosome band | % (n/MUM1+only) | Chromosome band | % (n/BCL6+MUM1+) | ||||
| 1q31 | 69 (9/13) | 3q13.2 | 64 (7/11) | ||||
| 1q24.2, 1q24.3, 1q25.1, 1q31.2, 1q31.3-q32.1 | 62 (8/13) | 11q24.3 | 64 (7/11) | ||||
| 1q22, 1q23.3, 1q25.1, 1q25.3, 1q31.1, 1q31.2, 1q31.3, 1q32.1 | 54 (7/13) | 3q12.3 | 55 (6/11) | ||||
| 3q29 | 54 (7/13) | 3q23 | 55 (6/11) | ||||
| 7q22-7q31.1 | 54 (7/13) | 7q22-7q31.1 | 55 (6/11) | ||||
| 9p24.2, 9p24.1, 9q34.3 | 54 (7/13) | 11-075-1 | 55 (6/11) | ||||
| 11q24.1, 11q24.3, | 54 (7/13) | 11q24.3 | 55 (6/11) | ||||
| 12p11.21, 12q12, 12q15, 12q21.33, 12q22, 12q24.31 | 54 (7/13) | 14q23.1c | 55 (6/11) | ||||
| 18q21 | 54 (7/13) | ||||||
| (d) Frequent regions of genomic losses in each subgroup of Non-GCB DLBCL identified by immunostaining | |||||||
| Non-GCB loss | |||||||
| MUM1 only |
BCL6+MUM1+ |
||||||
| Chromosome band | % (n/MUM1 only) | Chromosome band | % (n/BCL6+MUM1+) | ||||
| 14q32.13 | 54 (7/13) | 6q16.3 | 64 (7/11) | ||||
| 1p36.32, 1p36.23-31, 1p36.13 | 54 (7/13) | 6q12 | 55 (6/11) | ||||
| 2q21.1 | 54 (7/13) | 6q23.2, 6q23.3, 6q24.2, 6q25.3, 6q13, 6q15, 6q16.1, 6q16.2, 6q22.31, 6q22.33, | 45 (5/11) | ||||
| 8p21.3 | 54 (7/13) | 2q14.3 | 45 (5/11) | ||||
| 9p21.3 | 46 (6/13) | 8p21.3 | 45 (5/11) | ||||
| 14q24.3 | 46 (6/13) | 16q12.2 | 45 (5/11) | ||||
| 5p15 | 46 (6/13) | ||||||
| 5p15.32 | 46 (6/13) | ||||||
| 15q12, 15q26.1 | 46 (6/13) | ||||||
| 1p35.1, 1p34.3, 1q43 | 46 (6/13) | ||||||
| 2q12.2, 2q14.1 | 46 (6/13) | ||||||
| 6q21, 6q27 | 46 (6/13) | ||||||
| 8p23, 8q24.23 | 46 (6/13) | ||||||
| 10q22.3, 10q25.1 | 46 (6/13) | ||||||
| 15q11.2 | 46 (6/13) | ||||||
| 16q12.2 | 46 (6/13) | ||||||
| 16q23.3 | 46 (6/13) | ||||||
| 20q13.33 | 46 (6/13) | ||||||
Tables 4a–d: Copy number change of X chromosome was excluded. n, case numbers in each subgroup of GCB or non-GCB DLBCL identified by immunostaining. %, percentage of positive cases in each subgroup of GCB or non-GCB DLBCL identified by immunostaining.