Table 2.
Univariate and multivariate analysis of factors influencing survival in 61 patients with gastric cancer
| Parameter | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex | ||||||
| Female | Ref. | |||||
| Male | 1.271 | 0.702–1.532 | 0.5896 | NA | NA | NA |
| Age, years | ||||||
| <60 | Ref. | |||||
| ≥60 | 1.122 | 0.442–1.483 | 0.8593 | NA | NA | NA |
| Mucin phenotype | ||||||
| I and N type | Ref. | |||||
| G and GI type | 0.903 | 0.214–3.802 | 0.1003 | NA | NA | NA |
| Histology† | ||||||
| Intestinal | Ref. | |||||
| Diffuse | 1.601 | 0.254–1.473 | 0.2805 | NA | NA | NA |
| T grade‡ | ||||||
| T1/2 | Ref. | Ref. | ||||
| T3/4 | 4.886 | 1.136–3.225 | 0.0030 | 13.22 | 3.371–50.747 | <0.0010 |
| N grade‡ | ||||||
| N0 | Ref. | Ref. | ||||
| N1/2/3 | 9.234 | 1.388–16.667 | <0.0010 | 5.063 | 0.931–94.529 | 0.0625 |
| Stage‡ | ||||||
| 0/I/II | Ref. | Ref. | ||||
| III/IV | 8.460 | 2.083–11.111 | <0.0010 | 34.579 | 6.293–222.270 | <0.0010 |
| miR-148a expression | ||||||
| High | Ref. | Ref. | ||||
| Low | 10.820 | 1.785–20.000 | 0.0041 | 3.076 | 1.216–8.776 | 0.0169 |
†
Histology was determined according to the Japanese Classification of Gastric Cancer (14th edition).
‡
Tumor stage was classified according to the criteria of the International Union Against Cancer TNM classification of malignant tumors. CI, confidence interval; HR, hazard ratio; NA, not applicable; Ref., reference.