Table 2.

Univariate and multivariate Cox proportional hazard modeling of factors associated with relapse-free survival and tumor-specific survival in esophageal squamous cell carcinoma (ESCC) patient group (n = 92)

Variable	Subset	Univariate analysis			Multivariate analysis
		Hazard Ratio	95% CI	P-value	Hazard Ratio	95% CI	P-value
Relapse-free survival
Age (years)	>60/≤60	0.868	0.492–1.531	0.618			NA
Gender	Male/female	1.202	0.659–2.193	0.554			NA
Smoking status	Yes/no	1.323	0.744–2.351	0.319			NA
Drinking status	Yes/no	1.204	0.682–2.126	0.507			NA
T stage	T3+4/T1+2	2.366	1.341–4.174	0.003	1.539	0.816–2.903	0.185
Lymph node metastasis	Yes/no	4.686	2.641–8.316	<0.001	4.955	2.501–9.817	<0.001
MIC1	High/low	1.739	0.977–3.094	0.047	1.789	1.003–3.190	0.050
Tumor-specific survival
Age (years)	>60/≤60	0.749	0.394–1.387	0.338			NA
Gender	Male/female	1.167	0.594–2.295	0.659			NA
Smoking status	Yes/no	1.319	0.742–2.345	0.321			NA
Drinking status	Yes/no	1.483	0.788–2.791	0.206			NA
T stage	T3+4/T1+2	2.310	1.231–4.335	0.010	1.545	0.760–3.143	0.232
Lymph node metastasis	Yes/no	5.915	3.141–11.139	<0.001	5.720	2.376–13.772	<0.001
MIC1	High/low	2.557	1.341–4.873	0.002	2.625	1.347–5.115	0.005

MIC1, macrophage inhibitory factor 1.