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. 2014 Jul 25;105(8):1032–1039. doi: 10.1111/cas.12447

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig. 4 — Increased c-MET DNA copy numbers in PC-6 human small-cell lung cancer cells resistant to 7-ethyl-10-hydroxycamptothesin (PC-6/SN-38), paclitaxel (PC-6/TXL), and cisplatin (PC-6/CDDP), as well as the NCI-H69 and TXL-resistant NCI-H69 (H69/TXL) small-cell lung cancer cell lines. (a) c-MET DNA copy numbers in drug-resistant cells were examined relative to the parental cells by quantitative real-time PCR. (b) c-MET DNA copy numbers in PC-6 cells, exposed to 7-ethyl-10-hydroxycamptothesin (SN-38, 5 nM) or paclitaxel (TXL, 10 nM) for 7 days, were examined by quantitative real-time PCR. *P < 0.05.