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. 2014 Aug 27;105(8):1079–1085. doi: 10.1111/cas.12460

Fig. 2.

Fig. 2

Mutation characteristics. (a) Number of high-confidence somatic mutations across all foci. Non-silent, non-silent mutations; Unique, number of unique genes harboring a non-silent mutation; Reported, gene reported to be mutated in references 9–12 and 14. (b) Spectrum of unique high confidence somatic mutations across all foci. (c) Number of high-confidence somatic mutation types in all prostate samples. L, low-grade focus; H, high-grade focus; M, metastatic focus; NS, nonsynonymous; SYN, synonymous; UTR3, 3′ untranslated region; UTR5, 5′ untranslated region; SJ, splice junction; STOP, premature stop codon. (d) Confirmation of high-confidence somatic mutations with capillary sequencing by number of total and variant reads (gray, not confirmed; black, confirmed). Confirmation rate, 0.85.