Table 1.
Clinicopathological findings | Phenotypic mucin marker expression in tumor cells |
|||||||
---|---|---|---|---|---|---|---|---|
MUC5AC |
MUC6 |
MUC2 |
CD10 |
|||||
+/− n = 39/62 | P-value | +/− n = 54/47 | P-value | +/− n = 22/79 | P-value | +/− n = 23/78 | P-value | |
Mean age, years | 67.1/70.8 | 0.056 | 67.6/71.3 | 0.054 | 69.9/69.2 | 0.772 | 71.6/68.7 | 0.205 |
Gender | ||||||||
Male (n = 78) | 31/47 | 0.668 | 44/34 | 0.275 | 17/61 | 1.000 | 20/58 | 0.206 |
Female (n = 23) | 8/15 | 10/13 | 5/18 | 3/20 | ||||
Depth of invasion | ||||||||
T1 (n = 59) | 27/32 | 0.080 | 41/18 | <0.001* | 17/42 | 0.052 | 12/47 | 0.489 |
T2–4 (n = 42) | 12/30 | 13/29 | 5/37 | 11/31 | ||||
Lymphatic invasion | ||||||||
Negative (n = 51) | 23/28 | 0.176 | 36/15 | <0.001* | 15/36 | 0.060 | 13/38 | 0.511 |
Positive (n = 50) | 16/34 | 18/32 | 7/43 | 10/40 | ||||
Venous invasion | ||||||||
Negative (n = 57) | 26/31 | 0.100 | 41/16 | <0.001* | 17/40 | 0.030* | 12/45 | 0.639 |
Positive (n = 44) | 13/31 | 13/31 | 5/39 | 11/33 | ||||
Mean tumor size, mm | 40.8/44.0 | 0.862 | 34.6/52.2 | 0.004* | 37.3/44.3 | 0.247 | 42.2/43.0 | 0.900 |
Lymph node metastasis | ||||||||
N0 (n = 69) | 27/42 | 0.876 | 42/27 | 0.028* | 18/51 | 0.194 | 15/54 | 0.716 |
N1–3 (n = 32) | 12/20 | 12/20 | 4/28 | 8/24 | ||||
Distant metastasis | ||||||||
M0 (n = 94) | 38/56 | 0.244 | 52/42 | 0.246 | 21/73 | 1.000 | 22/72 | 1.000 |
M1 (n = 7) | 1/6 | 2/5 | 1/6 | 1/6 | ||||
Stage | ||||||||
I + II (n = 74) | 29/45 | 0.844 | 45/29 | 0.014* | 19/55 | 0.173 | 16/58 | 0.648 |
III + IV (n = 27) | 10/17 | 9/18 | 3/24 | 7/20 |
P < 0.05 was considered statistically significant. +, positive; −, negative.