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. 2013 Dec 30;105(1):64–71. doi: 10.1111/cas.12313

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© 2013 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.

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Injection of mesenchymal stem cells (MSCs) treated with interleukin (IL)-6 generated tumor formation in nude mice. (a) Tumors were observed in nude mice at the site injected with MSCs treated with IL-6 (arrow). (b) H&E staining of tissue from the cell injection site showed clusters of tumor cells with necrosis in the center (arrow). (c) No tumor growth was observed in nude mice after injection of normal control cells. (d) H&E staining of tissues at the cell injection site in the control group showed a normal skeletal muscle structure.