Table 1.
Association between CMTM3 expression and clinicopathological characteristics in 350 gastric cancer patients
| CMTM3 expression |
|||||
|---|---|---|---|---|---|
| n | Negative (%) | Positive (%) | χ2 | P-value | |
| Gender | |||||
| Male | 254 | 140 (40) | 114 (32.57) | 4.551 | 0.033 |
| Female | 96 | 65 (18.57) | 31 (8.86) | ||
| Age, years (median, 61) | |||||
| ≤60 | 172 | 101 (28.86) | 71 (20.29) | 0.003 | 0.955 |
| >60 | 178 | 104 (29.71) | 74 (21.14) | ||
| Primary tumor location | |||||
| Cardia | 96 | 54 (15.47) | 42 (12.03) | 0.265 | 0.607 |
| Non-cardia | 253 | 150 (42.98) | 103 (29.51) | ||
| No record† | 1 | ||||
| Tumor size | |||||
| <5 cm | 183 | 104 (30.05) | 79 (22.83) | 0.542 | 0.461 |
| ≥5 cm | 163 | 99 (28.61) | 64 (18.92) | ||
| No record† | 4 | ||||
| Gastrectomy | |||||
| Total | 48 | 30 (8.57) | 18 (5.14) | 0.792 | 0.673 |
| Proximal | 103 | 57 (16.29) | 46 (13.14) | ||
| Distal | 199 | 118 (33.71) | 81 (23.14) | ||
| Borrmann type | |||||
| Borrmann I | 35 | 18 (5.64) | 17 (5.33) | 1.958 | 0.581 |
| Borrmann II | 97 | 59 (18.50) | 38 (11.91) | ||
| Borrmann III | 156 | 98 (30.72) | 58 (18.18) | ||
| Borrmann IV | 31 | 17 (5.33) | 14 (4.39) | ||
| Early | 25 | ||||
| No record† | 6 | ||||
| Tumor depth | |||||
| T1 | 25 | 11 (3.14) | 14 (4) | 7.852 | 0.049 |
| T2 | 37 | 16 (4.57) | 21 (6) | ||
| T3 | 50 | 28 (8) | 22 (6.29) | ||
| T4 | 238 | 150 (42.86) | 88 (25.14) | ||
| Lymph node metastasis | |||||
| N0 | 82 | 43 (12.29) | 39 (11.14) | 2.288 | 0.683 |
| N1 | 52 | 30 (8.57) | 22 (6.29) | ||
| N2 | 69 | 40 (11.43) | 29 (8.29) | ||
| N3a | 98 | 61 (17.43) | 37 (10.57) | ||
| N3b | 49 | 31 (8.86) | 18 (5.14) | ||
| Distant metastasis | |||||
| M0 | 313 | 181 (51.71) | 132 (37.71) | 0.675 | 0.411 |
| M1 | 37 | 24 (6.86) | 13 (3.71) | ||
| Stage | |||||
| I | 44 | 19 (5.43) | 25 (7.14) | 9.695 | 0.021 |
| II | 51 | 24 (6.86) | 27 (7.71) | ||
| III | 218 | 138 (39.43) | 80 (22.86) | ||
| IV | 37 | 24 (6.86) | 13 (3.71) | ||
| Hepatic metastasis | |||||
| Absent | 323 | 185 (52.86) | 138 (39.43) | 2.898 | 0.089 |
| Present | 27 | 20 (5.71) | 7 (2) | ||
| Peritoneal metastasis | |||||
| Absent | 327 | 191 (54.57) | 136 (38.86) | 0.054 | 0.817 |
| Present | 23 | 14 (4) | 9 (2.57) | ||
| Histological type | |||||
| Adenocarcinoma | 272 | 158 (45.14) | 114 (32.57) | 0.117 | 0.732 |
| Other types‡ | 78 | 47 (13.43) | 31 (8.86) | ||
| V/L invasion | |||||
| Absent | 162 | 97 (28.03) | 65 (18.79) | 0.050 | 0.823 |
| Present | 184 | 108 (31.21) | 76 (21.97) | ||
| No record† | 4 | ||||
| Histological grade | |||||
| Well | 12 | 6 (1.74) | 6 (1.74) | 9.673 | 0.022 |
| Moderately | 134 | 68 (19.71) | 66 (19.13) | ||
| Poorly | 174 | 109 (31.59) | 65 (18.84) | ||
| Undifferentiated | 25 | 20 (5.80) | 5 (1.45) | ||
| No record† | 5 | ||||
†
Data incomplete.
‡
Signet-ring cell carcinoma, mucinous adenocarcinoma. V/L, vascular/lymphatic.