Table 1.
Distribution of characteristics in Chinese patients with non-small-cell lung cancer (n = 506) and prognosis analysis
| Variables | No. of total patients |
Overall survival |
Recurrence-free survival |
||||
|---|---|---|---|---|---|---|---|
| Deaths | HR (95% CI)† | P-value | Recurrence | HR (95% CI)† | P-value | ||
| n = 506, no. (%) | n = 159, no. (%) | n = 220, no. (%) | |||||
| Age | |||||||
| ≤59 years | 251 (49.6) | 77 (48.4) | Ref. | 117 (53.2) | Ref. | ||
| >59 years | 255 (50.4) | 82 (51.6) | 0.99 (0.72–1.38) | 0.974 | 103 (46.8) | 0.87 (0.66–1.15) | 0.340 |
| Gender | |||||||
| Female | 114 (22.5) | 36 (22.6) | Ref. | 54 (24.5) | Ref. | ||
| Male | 392 (77.5) | 123 (77.4) | 0.97 (0.57–1.66) | 0.917 | 166 (75.5) | 1.12 (0.71–1.78) | 0.622 |
| Smoking status | |||||||
| Never smoker | 160 (31.6) | 50 (31.4) | Ref. | 75 (34.1) | Ref. | ||
| Ever smoker | 346 (68.4) | 109 (68.6) | 0.97 (0.59–1.58) | 0.894 | 145 (65.9) | 0.78 (0.51–1.17) | 0.231 |
| Histology | |||||||
| Squamous cell carcinoma | 271 (53.6) | 82 (51.6) | Ref. | 112 (50.9) | Ref. | ||
| Adenocarcinoma | 152 (30.0) | 35 (22.0) | 0.61 (0.39–0.93) | 0.022 | 59 (26.8) | 0.77 (0.54–1.09) | 0.135 |
| Others‡ | 83 (16.4) | 42 (26.4) | 1.35 (0.83–2.22) | 0.230 | 49 (22.3) | 1.11 (0.72–1.71) | 0.643 |
| TNM stage | |||||||
| I/II | 284 (56.1) | 72 (45.3) | Ref. | 98 (44.5) | Ref. | ||
| III | 222 (43.9) | 87 (54.7) | 1.94 (1.41–2.68) | <0.001 | 122 (55.5) | 2.01 (1.53–2.65) | <0.001 |
| Differentiation | |||||||
| Well/moderate | 347 (68.6) | 88 (55.3) | Ref. | 129 (58.6) | Ref. | ||
| Poorly/undifferentiated | 159 (31.4) | 71 (44.7) | 1.50 (0.99–2.26) | 0.053 | 91 (41.4) | 1.61 (1.14–2.28) | 0.007 |
| Adjuvant chemotherapy or radiotherapy | |||||||
| No | 131 (25.9) | 46 (28.9) | Ref. | 54 (24.5) | Ref. | ||
| Yes | 375 (74.1) | 113 (71.1) | 0.67 (0.47–0.96) | 0.030 | 166 (75.5) | 0.86 (0.62–1.19) | 0.365 |
†
Adjusted by age, gender, smoking status, histology, TNM stage, differentiation, and adjuvant chemotherapy or radiotherapy where appropriate.
‡
Other carcinomas include adenosquamous carcinoma, large cell carcinoma, carcinosarcoma, and mucoepidermoid carcinoma. CI, confidence interval; HR, hazard ratio; Ref., reference.