Table 3.
Association between single nucleotide polymorphisms (SNPs) in the EpCAM gene and disease progression in Chinese patients with non-small-cell lung cancer
| SNP | Genotype | T stage |
N stage |
||||||
|---|---|---|---|---|---|---|---|---|---|
| T1/T2 (%) | T3/T4 (%) | OR (95% CI) | P-value | N0 (%) | N1/N2/N3 (%) | OR (95% CI) | P-value | ||
| rs1421 | AA | 192 (63.0) | 137 (72.5) | Ref. | 148 (65.5) | 181 (67.5) | Ref. | ||
| AG | 101 (33.1) | 46 (24.3) | 0.64 (0.42–096) | 0.033 | 70 (31.0) | 77 (28.7) | 0.89 (0.61–1.33) | 0.594 | |
| GG | 12 (3.9) | 6 (3.2) | 0.70 (0.26–1.91) | 0.488 | 8 (3.5) | 10 (3.7) | 1.02 (0.39–2.66) | 0.964 | |
| AG+GG | 113 (37.0) | 52 (27.5) | 0.65 (0.44–0.96) | 0.029 | 78 (34.5) | 87 (32.5) | 0.91 (0.63–1.33) | 0.630 | |
| rs1126497 | CC | 215 (69.4) | 121 (62.7) | Ref. | 157 (68.0) | 179 (65.8) | Ref. | ||
| CT | 90 (29.0) | 67 (34.7) | 1.32 (0.89–1.95) | 0.156 | 72 (31.2) | 85 (31.3) | 1.04 (0.71–1.51) | 0.857 | |
| TT | 5 (1.6) | 5 (2.6) | 1.78 (0.50–6.26) | 0.371 | 2 (0.9) | 8 (2.9) | 3.51 (0.73–16.77) | 0.116 | |
| CT+TT | 95 (30.6) | 72 (37.3) | 1.35 (0.92–1.97) | 0.123 | 74 (32.0) | 93 (34.2) | 1.10 (0.76–1.60) | 0.609 | |
N stage, regional lymph node involvement; Ref., reference; T stage, size and tissue invasion of the primary tumor.