Table 2.
Number of patients, n (%) |
|||
---|---|---|---|
Preferred term | Cohort 1 (10 mg/kg) n = 3 | Cohort 2 (20 mg/kg) n = 7 | Cohort 3 (15 mg/kg) n = 6 |
Patients with any AE | 1 (33.3) | 6 (85.7) | 1 (16.7) |
Hematologic | |||
Anemia | 0 | 1 (14.3) | 0 |
Leukopenia | 0 | 1 (14.3) | 0 |
Non-hematologic | |||
Aspartate aminotransferase increased | 0 | 2 (28.6) | 0 |
Cough | 1 (33.3) | 0 | 0 |
Dermatitis | 0 | 0 | 1 (16.7) |
Diarrhea | 0 | 1 (14.3) | 0 |
Fatigue | 0 | 1 (14.3) | 0 |
Fibrin D-dimer increased | 0 | 1 (14.3) | 0 |
Hyperglycemia | 0 | 1 (14.3) | 0 |
Hypertension | 0 | 1 (14.3) | 0 |
Proteinuria | 0 | 3 (42.9) | 1 (16.7) |
Rash | 0 | 1 (14.3) | 0 |
Tumor hemorrhage | 0 | 1 (14.3) | 0 |
For each preferred term, each patient is counted only once per preferred term.
AEs with missing relationship to study drug were considered as related. AE, adverse event.